|
rs201558687
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.
|
25373139 |
2014 |
|
rs4606
|
|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Women carrying the rs4606 CG or GG genotype are at elevated risk for developing hypertension after delivery.
|
24593135 |
2014 |
|
rs137852704
|
|
Hypertensive disease
|
T |
0.700 |
CausalMutation
|
CLINVAR |
Whole-exome sequencing reveals an inherited R566X mutation of the epithelial sodium channel β-subunit in a case of early-onset phenotype of Liddle syndrome.
|
27900368 |
2016 |
|
rs9375813
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we evaluated the associations between the CRP-related SNPs with cardiovascular disease phenotypes, rs9375813 (ARG1) showed a marginal association with hypertension (P = 0.0440).
|
24763700 |
2014 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
When the cohort was stratified by sex, ACE rs4362 and AGT rs699 showed significant associations with WMLs in men only (P = 0.01 and P = 0.03, respectively), and remained significant after controlling for hypertension.
|
24622918 |
2014 |
|
rs4362
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
When the cohort was stratified by sex, ACE rs4362 and AGT rs699 showed significant associations with WMLs in men only (P = 0.01 and P = 0.03, respectively), and remained significant after controlling for hypertension.
|
24622918 |
2014 |
|
rs2288646
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
When a second independent group of 403 individuals was combined with the first group of 551 (n=954), a significantly higher frequency of the rs2288646-A-containing genotype was observed in participants with hypertension (9.7 vs. 4.0%, P=0.003).
|
18854755 |
2008 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We, via a comprehensive meta-analysis, ascertained the role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T-786C polymorphism in Whites.
|
21912683 |
2011 |
|
rs5370
|
|
Hypertensive disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
We used generalised linear modelling to test K198N for association with hypertension and systolic blood pressure, lipid levels, insulin resistance scores and metabolic syndrome in a general cross-sectional community sample.
|
18288492 |
2008 |
|
rs8192678
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We used conventional meta-analysis methods to assess the association between Gly482Ser and systolic (SBP) or diastolic blood pressures (DBP) or hypertension in 13,949 individuals from 17 studies, of which 6,042 were previously unpublished observations.
|
18467552 |
2008 |
|
rs2576178
|
|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
We undertook allele, genotype, and haplotype association studies in all the cases and in the subgroups, as well as multiple factor analysis by logistic regression. rs10887800 and rs2576178 were significantly associated with ischemic stroke with hypertension by logistic regression (p = 0.041 and p = 0.038, respectively).
|
23564542 |
2013 |
|
rs10887800
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We undertook allele, genotype, and haplotype association studies in all the cases and in the subgroups, as well as multiple factor analysis by logistic regression. rs10887800 and rs2576178 were significantly associated with ischemic stroke with hypertension by logistic regression (p = 0.041 and p = 0.038, respectively).
|
23564542 |
2013 |
|
rs6499857
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore selected four tag polymorphisms (rs2304483, rs5804, rs8063291 and rs6499857) from SLC12A3 gene to investigate their individual and interactive associations with hypertension in northeastern Han Chinese.
|
24430698 |
2014 |
|
rs8063291
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore selected four tag polymorphisms (rs2304483, rs5804, rs8063291 and rs6499857) from SLC12A3 gene to investigate their individual and interactive associations with hypertension in northeastern Han Chinese.
|
24430698 |
2014 |
|
rs9333025
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We therefore investigated the association between a CYP4A11 polymorphism (rs9333025) with hypertension in the Mongolian and Han ethnic groups.
|
24535879 |
2014 |
|
rs2070744
|
|
Hypertensive disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
We therefore aimed to meta-analyze three eNOS widely-evaluated polymorphisms, G894T (rs1799983) in exon 7, 4b/a in intron 4, and T-786C (rs2070744) in promoter region, in association with hypertension from both English and Chinese publications, while addressing between-study heterogeneity and publication bias.
|
21912683 |
2011 |
|
rs10757278
|
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
We tested whether two single-nucleotide polymorphisms (SNPs) (rs2383207 and rs10757278), previously strongly associated with myocardial infarction, are independently associated with stroke and coronary events in patients with hypertension.
|
19293724 |
2009 |
|
rs2383207
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We tested whether two single-nucleotide polymorphisms (SNPs) (rs2383207 and rs10757278), previously strongly associated with myocardial infarction, are independently associated with stroke and coronary events in patients with hypertension.
|
19293724 |
2009 |
|
rs2294757
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that the rs2294757 VNN1 T26I polymorphism could affect blood pressure (BP) levels, hypertension prevalence, and risk of incident cardiovascular events.
|
21550219 |
2013 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the relation between the M235T polymorphism of the angiotensinogen gene and hypertension using office and ambulatory (BP) measurements.
|
9194517 |
1997 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the effects of the angiotensinogen T174M and M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of hypertension among Hispanics.
|
18497458 |
2008 |
|
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the effects of the angiotensinogen T174M and M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of hypertension among Hispanics.
|
18497458 |
2008 |
|
rs4762
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the effects of the angiotensinogen T174M and M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of hypertension among Hispanics.
|
18497458 |
2008 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the association between the Glu298Asp polymorphism of the NO producing gene, endothelial nitric oxide synthase (eNOS), and hypertension, left ventricular mass (LVM) and carotid artery intima-media thickness (IMT) in a population-based cohort of hypertensive and control subjects.
|
11905585 |
2002 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied eNOS polymorphisms in the promoter region (T-786C), in exon 7 (Glu298Asp), and in intron 4 (b/a) in 98 controls, 68 patients with HT, 66 patients with T2DM, and 86 patients with T2DM+HT.
|
17306574 |
2007 |